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Christ carries the cross, on his way to Golgotha. Behind him is Simon of Cyrene, who helps to bear the weight of the cross. The fainting Virgin is supported by the three other Maries. Saint John the Evangelist, beside her, wrings his hands. NG 2919 was the central scene of the predella below an altarpiece of the Virgin and Child with Saints, known today as the Colonna Altarpiece. This altarpiece was made for the church of S. Antonio, Perugia, in about 1504-5. The centre panel surmounted by a lunette as well as a part of the predella are now in New York (Metropolitan Museum of Art). Other parts of the predella exist in Boston (Isabella Stewart Gardner Museum) and London (Dulwich Picture Gallery).

Sold by the nuns of S. Antonio, Perugia, to Queen Christina of Sweden, 1663; bought by the Duc d'Orléans, 1721; subsequently in the Hibbert and Miles collections; collection of the Earl of Plymouth (Lord Windsor) by about 1893; from whom bought, 1913.